Design, synthesis and antidepressive activity of duloxetine derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 869-873, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-354562
ABSTRACT
In this paper, duloxetine was chosen as the lead compound. The pharmacophores with 5-HT(1A) antagonism activity were used to replace the naphthyl of duloxetine. A series of duloxetine derivatives had been designed and synthesized and whose structures were confirmed with elemental analysis, MS and H NMR. All synthesized compounds were tested by tail suspension test and forced swimming test in vivo. The test results revealed that most of the compounds have shown better activity than duloxetine at the same dosage. Some of them are worth to be studied further.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Relación Estructura-Actividad
/
Natación
/
Tiofenos
/
Estructura Molecular
/
Química
/
Suspensión Trasera
/
Antagonistas del Receptor de Serotonina 5-HT1
/
Clorhidrato de Duloxetina
/
Ratones Endogámicos ICR
Límite:
Animales
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2010
Tipo del documento:
Artículo
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