Design and synthesis of nitrogen-containing benzoheterocyclic derivatives and their antipsychotic activities / 药学学报
Acta Pharmaceutica Sinica
;
(12): 994-1001, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-354606
ABSTRACT
A series of nitrogen-containing benzoheterocyclic derivatives were synthesized and tested for their antipsychotic activities. Their structures were confirmed by 1H NMR and HR-MS. Preliminary in vitro pharmacological trials showed that most of the target compounds have high affinity with D2 and 5-HT(2A) receptors. Among the tested compounds, 20 exhibited the highest affinity and D2 partial agonist activity. In vivo studies showed 20 has potent antipsychotic activities on apomorphine mice model, which is a chance to find a better precursor of D2 partial agonist for further optimization.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Relación Estructura-Actividad
/
Antipsicóticos
/
Diseño de Fármacos
/
Receptores de Dopamina D2
/
Agonistas de Dopamina
/
Isoquinolinas
Límite:
Animales
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2009
Tipo del documento:
Artículo
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