A multicenter clinical study of nafate for treatment of hepatic fibrosis in patients with chronic liver diseases / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 749-752, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-354642
ABSTRACT
<p><b>OBJECTIVES</b>To investigate the effect of nafate (compound fetal cow liver extract tablets) in hepatic fibrosis patients with chronic liver diseases.</p><p><b>METHODS</b>One hundred fifteen hepatic fibrosis patients with chronic liver diseases from 3 medical centers were included in this study. All patients were given nafate orally for twenty-four weeks. Before treatment and 12, 24 and 36 weeks after the treatment, serum levels of hyaluronic acid (HA), laminin (LN) and type IV collagen (IV-C) of the patients were measured by radioimmunoassay and their liver biopsy specimens were also assessed.</p><p><b>RESULTS</b>Before treatment and 24 and 36 weeks after the nafate treatment, serum levels of HA were (279.2+/-81.4) ng/ml, (136.8+/-56.7) ng/ml and (86.9+/-40.7) ng/ml respectively, serum levels of LN were (170.8+/-73.0) ng/ml, (112.5+/-39.5) ng/ml, and (60.8+/-31.8) ng/ml respectively, and IV-C levels were (153.7+/-60.1) ng/ml, (112.4+/-43.1) ng/ml, and (96.3+/-44.1) ng/ml respectively. There was a significant reduction in these serum values after the treatments. Histopathological examinations of the liver biopsies showed that the degree of hepatic fibrosis obviously declined by one or two degrees after the treatments.</p><p><b>CONCLUSIONS</b>nafate has positive effects in treating hepatic fibrosis.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Terapéutica
/
Usos Terapéuticos
/
Combinación de Medicamentos
/
Cirrosis Hepática
/
Extractos Hepáticos
Tipo de estudio:
Ensayo Clínico Controlado
Límite:
Animales
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Hepatology
Año:
2007
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS