Complete genome sequence characteristics of human enterovirus 71 strain isolated in Yunnan, China / 病毒学报
Chinese Journal of Virology
; (6): 108-113, 2012.
Article
en Zh
| WPRIM
| ID: wpr-354762
Biblioteca responsable:
WPRO
ABSTRACT
The complete nucleotide sequence of two human enterovirus 71 strains (KMM09 and KM186-09) isolated in Yunnan,China, were determined by RT-PCR and sequencing. As with other human enteroviruses, the genomes were 7 409 nucleotides (nts) in length and encoded 2 193 aa. Phylogenetic analysis based on VP1 regions revealed that the two isolates belonged to subgenotype C4a. In structural genomic regions, subgenotype C4 was most homologous to other strains of C genotype when compared to other genotypes. In non-structural genomic regions, subgenotype C4 was more homologous to CA16/G10 and other strains of B genotype than to other strains of C genotype. RDP3 and Blast analysis displayed evidence of recombination in non-structural genomic regions between subgenotype B3 and C4, C4 and CA16/G10. The full-length genome of the human enterovirus 71 strains provided an overview of the diversity of genetic characteristics of a circulatinghuman enterovirus 71.
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Filogenia
/
Virología
/
Células Vero
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Datos de Secuencia Molecular
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Secuencia de Bases
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Chlorocebus aethiops
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China
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Clasificación
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Genoma Viral
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Enterovirus Humano A
Límite:
Animals
/
Humans
País/Región como asunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Virology
Año:
2012
Tipo del documento:
Article