Expression of microRNA-21 in ovarian epithelial carcinoma and its clinical significance / 南方医科大学学报
Journal of Southern Medical University
;
(12): 608-613, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-355058
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of microRNA-21(miR-21) in ovarian epithelial carcinoma and its association with the clinicopathological features.</p><p><b>METHODS</b>The expression of miR-21 was detected by Stem-loop real-time RT-PCR in 48 cases of ovarian epithelial carcinomas, 24 cases of benign ovarian epithelial tumors and 15 cases of normal ovarian tissues.</p><p><b>RESULTS</b>The relative expression level of miR-21(2-(DeltaDelta)CT) was 4.849-/+1.813 in the ovarian epithelial carcinomas, significantly higher than that in the benign ovarian tumors and normal ovarian tissues (P<0.01), but comparable between the latter two groups. The expression of miR-21 was not correlated to the histological type, but increased significantly with the progression of the clinical stages and histological grading (P<0.01), showing a close correlation to lymphatic metastasis.</p><p><b>CONCLUSION</b>MiR-21 might play a role as an oncogene in the tumorigenesis and development of ovarian epithelial carcinoma, and is possibly correlated to the progression and prognosis of ovarian epithelial carcinoma.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias Ováricas
/
Pronóstico
/
Regulación Neoplásica de la Expresión Génica
/
Cistadenocarcinoma Seroso
/
MicroARNs
/
Genética
/
Metástasis Linfática
/
Metabolismo
Tipo de estudio:
Estudio pronóstico
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2010
Tipo del documento:
Artículo
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