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Effects of rosuvastatin on left ventricular cardiac function, arteriosclerotic plaque and high sensitive C-reactive protein in hypertensive patients with mild LDL-C elevation / 南方医科大学学报
Journal of Southern Medical University ; (12): 588-590, 2010.
Artículo en Chino | WPRIM | ID: wpr-355064
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of rosuvastatin on left ventricular cardiac function, arteriosclerotic plaque and high sensitive C-reactive protein (hs-CRP) in hypertensive patients with mild elevation of LDL-C.</p><p><b>METHODS</b>Seventy-nine patients with a SBP of 140-179 mmHg and/or a DBP of 90-109 mmHg and mild elevated LDL-C were treated with rosuvastatin for 12 months (n=40) or not (n=39). The changes of hs-CRP, arteriosclerosis plaque and cardiac function at the end of the 12-months treatment relative to the baseline levels were analyzed.</p><p><b>RESULTS</b>After 12 months of treatment, LDL-C was decreased by 33.2% in rosuvastatin group but remained unchanged in patients without rosuvastatin treatment. The left ventricular peak filling rate (LVPFR) increased significantly from 1.85 to 2.59 (P<0.05) and the serum levels of hs-CRP reduced significantly (P<0.05) after rosuvastatin treatment. The size of the plaques reduced significantly after a 12-month rosuvastatin therapy.</p><p><b>CONCLUSION</b>Rosuvastatin therapy on the basis of conventional anti-hypertensive drugs can obviously improve the left ventricular diastolic function and produce favorable effects on arteriosclerotic plaques.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Arteriosclerosis / Pirimidinas / Sulfonamidas / Sangre / Proteína C-Reactiva / Función Ventricular Izquierda / Inhibidores de Hidroximetilglutaril-CoA Reductasas / Usos Terapéuticos / Quimioterapia Tipo de estudio: Estudio diagnóstico Límite: Anciano / Femenino / Humanos / Masculino Idioma: Chino Revista: Journal of Southern Medical University Año: 2010 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Arteriosclerosis / Pirimidinas / Sulfonamidas / Sangre / Proteína C-Reactiva / Función Ventricular Izquierda / Inhibidores de Hidroximetilglutaril-CoA Reductasas / Usos Terapéuticos / Quimioterapia Tipo de estudio: Estudio diagnóstico Límite: Anciano / Femenino / Humanos / Masculino Idioma: Chino Revista: Journal of Southern Medical University Año: 2010 Tipo del documento: Artículo