Progesterone promotes the proliferation and migration of cultured breast cancer cells / 南方医科大学学报
Journal of Southern Medical University
; (12): 443-446, 2010.
Article
en Zh
| WPRIM
| ID: wpr-355105
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of progesterone on the growth and migration of breast cancer cells.</p><p><b>METHODS</b>MCF-7 and T-47D cells were cultured in DMEM and stimulated with 100 nmol/L progesterone for 48 h, and the cell proliferation was evaluated by MTT assay, cell migration by wound-healing assay and E-catherin expression by Western blotting.</p><p><b>RESULTS</b>Progesterone stimulated the cell proliferation and migration and down-regulated the expression of E-catherin in both MCF-7 and T-47D cells.</p><p><b>CONCLUSIONS</b>Progesterone stimulates the cell proliferation and migration of cultured breast cancer cells, suggesting the clinical significance of anti-progesterone therapy in breast cancer.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Patología
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Farmacología
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Progesterona
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Neoplasias de la Mama
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Células Tumorales Cultivadas
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Cadherinas
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Movimiento Celular
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Proliferación Celular
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Metabolismo
Límite:
Female
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Humans
Idioma:
Zh
Revista:
Journal of Southern Medical University
Año:
2010
Tipo del documento:
Article