Sequential changes in biomechanical competence of femoral neck and marrow cavity of proximal femur in ovariectomized rats / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 432-446, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-355189
ABSTRACT
<p><b>OBJECTIVE</b>To observe the sequential changes in biomechanical competence of the femoral neck and marrow cavity of the proximal femur in ovariectomized rats.</p><p><b>METHODS</b>Bone mineral density (BMD) and biomechanical properties of the femoral neck and the structural dimension of the proximal femur were measured 0, 3, 6, 9, 12, 15, 18, 21 weeks after ovariectomy (OVX) or sham operation (Sham) in 6-month-old female SD rats.</p><p><b>RESULTS</b>The BMD of femoral neck in OVX rats was significantly lower than that in Sham group 6 weeks after operation, (0.195 +/-0.028) g/mm(2) vs (0.225 +/-0.036) g/mm(2) (P=0.03). Nine weeks after operation,the failure load of femoral neck decreased about 10% in OVX group to that in Sham group, (89.6 +/-7.7)N vs (96.7 +/-7.5)N (P=0.05). The medullary cavity of proximal femur started to show difference 15 weeks after operation (3.834 +/-0.115)mm(2) vs (3.713 +/-0.114) mm(2) (P=0.03).</p><p><b>CONCLUSION</b>BMD loss after ovariectomy is associated with a medullary expansion in proximal femur and biomechanical strength deterioration in femoral neck, which might be an important factor of prostheses loosening in the postmenopausal osteoporotic women.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fenómenos Biomecánicos
/
Falla de Prótesis
/
Ovariectomía
/
Distribución Aleatoria
/
Densidad Ósea
/
Osteoporosis Posmenopáusica
/
Ratas Sprague-Dawley
/
Artroplastia de Reemplazo de Cadera
/
Fémur
/
Cuello Femoral
Tipo de estudio:
Ensayo Clínico Controlado
Límite:
Animales
/
Femenino
/
Humanos
Idioma:
Chino
Revista:
Journal of Zhejiang University. Medical sciences
Año:
2005
Tipo del documento:
Artículo
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