Comparison of methods to detect insulin resistance in obese children and adolescents / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>To explore the practical and sensitive index for insulin resistance in obese children and adolescents.</p><p><b>METHODS</b>An oral glucose tolerance test and insulin releasing test were performed in 126 obese (divided into 3 groups according their BMI) and 25 normal children. The ratio of fasting plasma glucose to fasting plasma insulin (FBG/FINS), homeostasis model assessment-insulin resistance (HOMA-IR), homeostasis model assessment-insulin activity index (IAI), whole body insulin sensitivity index (WBISI) and area under curve of glucose and insulin (AUCBG, AUCINS) were calculated.</p><p><b>RESULT</b>There were no significant differences in fasting plasma glucose levels, while significant differences existed in fasting plasma insulin, the ratio of fasting plasma glucose to fasting plasma insulin,homeostasis model assessment-insulin resistance, homeostasis model assessment-insulin activity index, whole body insulin sensitivity index, area under curve of glucose, area under curve of insulin and AUCINS/AUCBG among these four groups. Whole body insulin sensitivity index (WBISI) reflected the sensitiveness of the insulin earlier than that of homeostasis model assessment-insulin resistance and homeostasis model assessment-insulin activity index.</p><p><b>CONCLUSION</b>Whole body insulin sensitivity index seems to be a better index for insulin resistance for obese children.</p>