Diagnostic value of quantitative low-dose dobutamine stress echocardiography with three-dimensional speckle-tracking for non-ST-elevation acute coronary syndrome / 南方医科大学学报
Journal of Southern Medical University
; (12): 947-953, 2015.
Article
en Zh
| WPRIM
| ID: wpr-355251
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To access left ventricular global deformation abnormalities during low-dose dobutamine stress test (DSE) by three-dimensional speckle-tracking echocardiography(3D-STE)in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS), and explore the diagnostic value of 3D-STE combined with DES for NSTE-ACS.</p><p><b>METHODS</b>Forty-nine patients with suspected NSTE-ACS underwent DSE and coronary angiography with an initial dobutamine dose of 5 µg·kg(-1)·min(-1), which was doubled at 3-min intervals to the peak dose of 20 µg·kg(-1)·min(-1). The global longitudinal strain (GLS), global circumferential strain (GCS), territory longitudinal strain (TLS), and territory circumferential strain (TCS) of the left ventricular subendocardial myocardium were measured with 3D-STE at rest and at the peak-dose stage. Conventional echocardiography and 3D-STE parameters and their changes during DSE were evaluated, and their diagnostic values were analyzed according to the receiver-operating characteristic (ROC) curves.</p><p><b>RESULTS</b>All the patients completed DSE uneventfully and 3D-STE showed a good reproducibility of the results. Compared with patients with non-NSTE-ACS, NSTE-ACS patients showed obviously reduced resting left ventricular global deformation function especially in terms of circumferential deformation (P<0.05); the ROC curves for the parameters were similar between the two groups (P>0.05). During DSE, the global deformation differences between the two groups further increased (P<0.01), and the diagnostic values of the peak-dose stage parameters were significantly greater than those of the resting parameters. ROC curves analysis showed that TLS and TCS at peak-dose stage had the highest diagnostic value for NSTE-ACS.</p><p><b>CONCLUSION</b>3D-STE combined with low-dose DSE is a safe and effective noninvasive technique for accessing and identifying NSTE-ACS, and DSE can significantly enhance the diagnostic value of 3D-STE.</p>
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Índice:
WPRIM
Asunto principal:
Patología
/
Reproducibilidad de los Resultados
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Curva ROC
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Angiografía Coronaria
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Ecocardiografía Tridimensional
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Ecocardiografía de Estrés
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Diagnóstico
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Síndrome Coronario Agudo
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Ventrículos Cardíacos
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Miocardio
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
Zh
Revista:
Journal of Southern Medical University
Año:
2015
Tipo del documento:
Article