The effects of rhG-CSF and rhSCF on peripheral blood leukocytes and CFU-GM in rhesus monkeys / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 381-384, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-355641
ABSTRACT
To evaluate the effects of rhG-CSF and rhSCF on mobilization of the peripheral blood stem cells, 15 monkeys were divided into control, rhG-CSF 10 micro g/(kg x day) and rhG-CSF 10 micro g/(kg x day) + rhSCF 50 micro g/(kg x day) treated groups. Monkeys were administered with vehicle, rhG-CSF and rhG-CSF + rhSCF subcutaneously once daily for 14 days, respectively. The results showed that the highest counts of leukocyte of rhG-CSF treated group were 411% of baseline value on day 7 after administration, compared with that of rhG-CSF + rhSCF treated group which were 538% on day 9. The highest counts of leukocytes lasted for 3 days in combined treated group. CFU-GM from peripheral blood in the two groups were 8.37 and 11.75 times higher at 5 and 9 days respectively after the mobilization. It is concluded that rhG-CSF significantly increases the number of peripheral blood leukocytes and CFU-GM, and a better effect can be obtained by rhSCF + rhG-CSF combined administration.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Proteínas Recombinantes
/
Células Madre Hematopoyéticas
/
Factor Estimulante de Colonias de Granulocitos
/
Factor de Células Madre
/
Quimioterapia Combinada
/
Recuento de Leucocitos
/
Leucocitos
/
Macaca mulatta
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Experimental Hematology
Año:
2003
Tipo del documento:
Artículo
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