Association between plasma macrophage migration inhibitory factor concentration and coronary artery lesion severity / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 912-915, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-355866
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between the plasma macrophage migration inhibitory factor (MIF), activator protein-1 (AP-1) and MMP-9 concentrations and the severity of coronary artery lesions in coronary heart disease (CHD) patients.</p><p><b>METHODS</b>Patients were divided into normal controls (n = 35), stable angina pectoris (SAP, n = 32) and acute coronary syndrome (ACS, n = 75) according to the coronary angiography (CAG), clinical and laboratory examinations. The CAG severity and extent of coronary lesions were analyzed by means of Gensini coronary score system. Enzyme linked immunosorent assay was used to measure the plasma MIF, AP-1 and MMP-9 concentrations.</p><p><b>RESULTS</b>Plasma MIF, AP-1 and MMP-9 concentrations were significant increased in CHD patients [MIF (14.97 +/- 2.11) microg/L, AP-1 1.43 +/- 0.33, MMP-9 (1.48 +/- 0.14) microg/L] compared to those in control group [MIF (9.07 +/- 1.28) microg/L, AP-1 0.71 +/- 0.13, MMP-9 (1.01 +/- 0.07) microg/L, all P < 0.05]. The MIF, AP-1 and MMP-9 concentrations in ACS group [MIF (16.66 +/- 2.56) microg/L, AP-1 1.56 +/- 0.22, MMP-9 (1.58 +/- 0.14) microg/L] were also significant higher than those in SAP group [MIF (11.01 +/- 2.12) microg/L, AP-1 1.04 +/- 0.25, MMP-9 (1.25 +/- 0.07) microg/L, all P < 0.05] and there was significant positive correlation between MIF, AP-1 and MMP-9 concentrations and the Gensini score of coronary artery lesions (all P < 0.05). AP-1 was positively correlated with MMP-9 in CHD patients (P < 0.05).</p><p><b>CONCLUSIONS</b>Plasma MIF, AP-1 and MMP-9 concentrations were positively correlated to the severity of coronary lesions in CHD patients. Higher MIF, AP-1 and MMP-9 concentrations in ACS patients than in SAP patients might suggest higher plaque instability in ACS patients.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Sangre
/
Enfermedad de la Arteria Coronaria
/
Factores Inhibidores de la Migración de Macrófagos
/
Angiografía Coronaria
/
Placa Aterosclerótica
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Cardiology
Año:
2008
Tipo del documento:
Artículo
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