Association of the beta2-adrenergic receptor gene C659G polymorphism and essential hypertension in Xinjiang Kazakans / 中华心血管病杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the relationship between human beta2-Adrenergic Receptor (ADRB2) gene C659G polymorphism and essential hypertension in Xinjiang Kazakans.</p><p><b>METHODS</b>Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) methods were used to detect the C659G polymorphism of ADRB2 gene in 435 Kazakans including 273 hypertensives (EH) and 162 normotensives (NT) and genotype frequencies between EH and NT were analyzed.</p><p><b>RESULTS</b>The genotype frequencies (CC, CG, GG) of the C659G allele were 85.75%, 13.79%, 0.64% respectively and the C659 and G659 allele frequencies were 7.36%, 92.64% in this cohort. The ADRB2 genotype distribution and the allele frequencies of C659 and G659 were significantly higher in EH than those in NT (all P < 0.05). The G allele is a risk factor contributed to hypertension (OR 12.37). After adjustment for age and BMI, the systolic and diastolic blood pressure levels were significant higher in CG + GG genotype group compared with CC genotype group (P < 0.05).</p><p><b>CONCLUSION</b>There was significant association between the C659G polymorphism of ADRB2 gene and essential hypertension in Xinjiang Kazakans suggesting a role of ADRB2 gene C659G polymorphism in the development of hypertension in Xinjiang Kazakans.</p>