Impact on absorption of berberine and palmatine in different compatibilities of Wuji pill / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 985-990, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-356030
ABSTRACT
<p><b>OBJECTIVE</b>To observe the impact on absorption of berberine and palmatine in different compatibilities of Wuji pill by the perfused rat intestine-liver preparation.</p><p><b>METHOD</b>Use L9 (3(4)) orthogonal design table, establish the perfused rat intestine-liver preparation, the twelve Wuji pill compatibilities duodenal administrated, collect the perfusate at different times points for LC-MS detection, calculate the absorbed score, Ka.</p><p><b>RESULT</b>Evodiae Fructus and the absorption score, Ka of berberine and palmatine are inverse correlated. The most superior portion which promote the absorption is Coptidis Rhizoma-Evodiae Fructus-Paeoniae Radix Alba 313.</p><p><b>CONCLUSION</b>Evodiae Fructus suppressed the absorption of berberine and palmatine. With the different portion the absorption also have big different.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Berberina
/
Alcaloides de Berberina
/
Medicamentos Herbarios Chinos
/
Farmacocinética
/
Química
/
Evodia
/
Absorción Intestinal
/
Metabolismo
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2012
Tipo del documento:
Artículo
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