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The impact of diabetes mellitus and insulin interference on cortical SCF/KIT of mice / 中国应用生理学杂志
Chinese Journal of Applied Physiology ; (6): 94-96, 2010.
Artículo en Chino | WPRIM | ID: wpr-356207
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of cortical SCF/KIT system at different blood glucose level in mice.</p><p><b>METHODS</b>27 male C57 mice were randomly divided into control group, diabetes group, and diabetes plus insulin group. The diabetic mice were induced by streptozotocin. Western-blot and double-immunofluorescence histochemistry were used to detect the expression of SCF and KIT.</p><p><b>RESULTS</b>Both methods indicate that the level of S-SCF and M-SCF were decreased significantly in the diabetes group, and this trend can be reversed effectively when the insulin was utilized.</p><p><b>CONCLUSION</b>The decline of SCF might be one of underlying mechanisms of diabetic encephalopathy.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fisiología / Regulación hacia Abajo / Corteza Cerebral / Factor de Células Madre / Proteínas Proto-Oncogénicas c-kit / Usos Terapéuticos / Diabetes Mellitus Experimental / Quimioterapia / Insulina / Metabolismo Límite: Animales Idioma: Chino Revista: Chinese Journal of Applied Physiology Año: 2010 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fisiología / Regulación hacia Abajo / Corteza Cerebral / Factor de Células Madre / Proteínas Proto-Oncogénicas c-kit / Usos Terapéuticos / Diabetes Mellitus Experimental / Quimioterapia / Insulina / Metabolismo Límite: Animales Idioma: Chino Revista: Chinese Journal of Applied Physiology Año: 2010 Tipo del documento: Artículo