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A chromatographic fingerprinting-based approach to evaluating the stability of production process of traditional Chinese medicine / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 1151-1162, 2006.
Artículo en Chino | WPRIM | ID: wpr-356720
ABSTRACT
<p><b>OBJECTIVE</b>To study a new method for the evaluation of the stability of production process of Traditional Chinese Medicines (TCM) based on chromatographic fingerprinting.</p><p><b>METHOD</b>Taking the extraction process of Red Ginseng for example, the fingerprints of extracts produced with fluctuating processing factors, i.e. ratio of solvent to liquid, solvent concentration, extraction durations and extraction times, were acquired. Meanwhile, the similarity of fingerprinting based on Euclidean distance was calculated and each fingerprint was fitwith cubic spline.</p><p><b>RESULT</b>Similarities of fingerprints of the extracts responded to the fluctuation of processing factors, and it showed that taking similarity as index, quantitative relation between chromatographic fingerprints and processing factors could be established.</p><p><b>CONCLUSION</b>The method proposed in the paper was able to describe the quality of products resulting from fluctuating conditions in extracting process, and therefore, can be developed as a practicable strategy to evaluate the stability Traditional Chinese Medicines in production process.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Plantas Medicinales / Control de Calidad / Solventes / Medicamentos Herbarios Chinos / Química / Cromatografía Líquida de Alta Presión / Tecnología Farmacéutica / Ginsenósidos / Estabilidad de Medicamentos / Estudios de Evaluación como Asunto Tipo de estudio: Estudio diagnóstico / Estudios de evaluación Idioma: Chino Revista: China Journal of Chinese Materia Medica Año: 2006 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Plantas Medicinales / Control de Calidad / Solventes / Medicamentos Herbarios Chinos / Química / Cromatografía Líquida de Alta Presión / Tecnología Farmacéutica / Ginsenósidos / Estabilidad de Medicamentos / Estudios de Evaluación como Asunto Tipo de estudio: Estudio diagnóstico / Estudios de evaluación Idioma: Chino Revista: China Journal of Chinese Materia Medica Año: 2006 Tipo del documento: Artículo