Effect of glaucocalyxin A on level of Th1/Th2 type cytokines in mice / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To research the effect of glaucocalyxin A (GLA) on the level of Th1/Th2 type cytokines in mice.</p><p><b>METHOD</b>By using flow cytometer with CBA software to detect Th1/Th2 type cytokines.</p><p><b>RESULT</b>GLA had insighificant inhibitory effects on Th1 and Th2 cytokines (IL-2, IFN-gamma,TNF-alpha, IL-4 and IL-5) induced by ConA, in which more potential on cytokines from Th1 than those of from Th2 were displayed. However, GLA could produce inhibition on IL-2, IFN-gamma and TNF-alpha and acceleration on IL-4 and IL-5.</p><p><b>CONCLUSION</b>Immunosuppressive effect of GLA is related to the influence the level of Th1/Th2 type cytokines.</p>