Homocysteine alters monocyte-endothelial interaction in vitro / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 34-38, 2003.
Artículo
en Inglés
| WPRIM
| ID: wpr-356874
ABSTRACT
<p><b>OBJECTIVE</b>To determine whether homocysteine induced endothelial damage through monocyte-endothelial interaction and to characterize both cell types in vitro.</p><p><b>METHODS</b>Radiomethods were performed on monocyte adhesion to/through endothelium and endothelial damage experiments.</p><p><b>RESULTS</b>Homocysteine-treated endothelial cells increased monocyte adhesion and transmigration. Homocysteine-treated monocytes induced endothelial detachment, but this effect was blocked by catalase. These effects were increased with higher concentrations of homocysteine. Monocyte surface glycoprotein antibodies CD11b/CD18 and CD14 inhibited these processes.</p><p><b>CONCLUSIONS</b>Homocysteine alters monocyte-endothelial interaction in vitro, eventually bringing about endothelial damage through release of H(2)O(2). These phenomena are mediated through monocyte surface glycoproteins CD11b/CD18 and CD14. Upregulation of these processes in vivo may contribute to acceleration of atherosclerosis in patients with elevated plasma homocysteine levels.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Fisiología
/
Arteriosclerosis
/
Endotelio Vascular
/
Monocitos
/
Adhesión Celular
/
Comunicación Celular
/
Movimiento Celular
/
Biología Celular
/
Relación Dosis-Respuesta a Droga
Límite:
Humanos
Idioma:
Inglés
Revista:
Chinese Medical Journal
Año:
2003
Tipo del documento:
Artículo
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