Expression of CD44v6 and E-cadherin in prostate carcinoma and metastasis of prostate carcinoma / 中华男科学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the expression of CD44v6 and E-cadherin(ED) in prostate carcinoma in relation to the metastasis of prostate carcinoma.</p><p><b>METHODS</b>The expression of CD44v6 and ED in 45 cases of prostate carcinoma was studied with immunohistochemical technique.</p><p><b>RESULTS</b>The positive expression rates of CD44v6 and ED in prostate carcinoma were 77.8% and 48.9%, respectively. The high level expression of CD44v6 and the low level expression of ED were positively correlated with differentiation, clinical staging and metastasis of prostate carcinoma (P < 0.05). The expression of CD44v6 was negatively correlated with ED(r = -0.58, P < 0.005).</p><p><b>CONCLUSIONS</b>The expression of CD44v6 and ED protein might be a useful marker for prostate carcinoma in evaluating the biological behavior and prognosis of the tumor.</p>