Correlation of IKZF1 Gene with Malignant Tumors and Systemic Lupus Erythematosus / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 591-595, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-357309
ABSTRACT
IKZF1 gene located in 7p12 of chromosome, and Ikaros family zinc finger encoded by IKZF1, are lymphoid-restricted transcription factors. In recent years, it has been demonstrated that the mutation of IKZF1 gene involved in proliferation, metastasis and prognosis of many malignant tumor except acute lymphoblastic leukemia, and also involved in complex phenotypes and susceptibility to systemic lupus erythematosus. This review briefly introduces the molecular structure and physiological function of Ikaros, focusing on its function and molecular mechanism in proliferation, metastasis and prognosis of malignant tumors, and its role in the systemic lupus erythematosus.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Factor de Transcripción Ikaros
/
Lupus Eritematoso Sistémico
/
Neoplasias
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Experimental Hematology
Año:
2015
Tipo del documento:
Artículo
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