Relationship between lipid peroxidation in blood and neurobehavioral function changes in coke oven workers / 中华劳动卫生职业病杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the coincidence of lipid peroxidation and neurobehavioral function changes in coke oven workers.</p><p><b>METHODS</b>One hundred and thirty-four coke oven workers were divided into three groups: 35 in the oven-bottom group, 49 in the oven-side group and 50 in oven-top group. WHO recommended NCTB was performed on coke oven workers and 36 controls from material conservation department; The contents of total superoxide dismutases (T-SOD), glutathione (GSH) and malondialdehyde (MDA) in blood were determined by test kits.</p><p><b>RESULTS</b>Compared with the controls, the coke oven workers showed lower levels of T-SOD and GSH (P < 0.01), significantly higher MDA levels in blood (P < 0.01), higher score on negative mood state, lower scores on positive mood state, and poorer performance in NCTB test (P < 0.05). Further analysis revealed that there was a weak positive correlation between neurobehavioral function changes and the level of lipid peroxidation with a coefficient lower than 0.25.</p><p><b>CONCLUSION</b>The level of lipid peroxidation in coke oven workers' blood increased and coincided with neurobehavioral function impairment.</p>