The degradation performance of chitin short fiber reinforced polycaprolactone composite in vitro / 生物医学工程学杂志

ABSTRACT

We have investigated the degradation of pure Polycaprolactone (PurePCL) and chitin short fiber reinforced Polycaprolactone composite (SFRP) in vitro in order to provide useful scientific basis for clinical application. PurePCL, SFRP and DL-PLA were immersed in 0.9% NaCL solution for periods of 2, 4, 8, 12, 16 and 24 weeks. Then pH values in immersing solution, weight loss and mechanical properties of tested materials were measured and SEM was used to study the change of the materials in the process of degradation. It was shown that the initial strength of SFRP was much higher than that of PurePCL. In the process of degradation of SFRP, the pH values maintained weak acid or remianed neutral. The rate of weight loss of SFRP was faster than that of PurePCL, but slower than that of DL-PLA. The strength and modulus of SFRP did not change much in 24 weeks, compared with the initial ones. In conclusion, the composites have excellent properties and may be optimal for clinical use in reconstruction of chest wall defects as well as in internal fixation of bone fracture.