An experimental study of energy controllable steep pulse in the treatment of rat with subcutaneous transplantive tumor / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 492-495, 2007.
Article
en Zh
| WPRIM
| ID: wpr-357667
Biblioteca responsable:
WPRO
ABSTRACT
This experimental study was designed to investigate the effects and the expressions of microvessel density (MVD), vascular endothelial growth factor (VEGF) on the transplanted tumor in the rat model with Walker-256 after energy controllable steep pulse(ECSP). The experiment revealed that the steep pulse electrical field has better effect on tumor, compared with the control. The positive cell staining intensity of VEGF in the control group was significantly higher than that in ECSP group (P < 0.05). The number of MVD in the tumor tissues of ECSP group was significantly lower than that of tumor control group (P < 0.05). These results showed that ECSP could inhibit the growth and angiogenesis of tumor and its pathway is to down-regulate the expression of VEGF possibly.
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Terapéutica
/
Carcinoma 256 de Walker
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Terapia por Estimulación Eléctrica
/
Ratas Wistar
/
Electroporación
/
Factor A de Crecimiento Endotelial Vascular
/
Conductividad Eléctrica
/
Campos Electromagnéticos
/
Metabolismo
/
Métodos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
Zh
Revista:
Journal of Biomedical Engineering
Año:
2007
Tipo del documento:
Article