Protein Interaction Network Construction and Biological Pathway Analysis Related to Atherosclerosis / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 1255-1260, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-357884
ABSTRACT
Atherosclerosis is a complex disease characterized by lipid accumulation in the vascular wall and influenced by multiple genetic and environmental factors. To understand the mechanisms of molecular regulation related to atherosclerosis better, a protein interaction network was constructed in the present study. Genes were collected in nucleotide database and interactions were downloaded from Biomolecular Object Network Database (BOND). The interactional data were imported into the software Cytoscape to construct the interaction network, and then the degree characteristics of the network were analyzed for Hub proteins. Statistical significance pathways and diseases were figured out by inputting Hub proteins to KOBAS2. 0. The complete pathway network related to atherosclerosis was constructed. The results identified a series of key genes related to atherosclerosis, which would be the potential promising drug targets for effective prevention.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Programas Informáticos
/
Bases de Datos Factuales
/
Mapeo de Interacción de Proteínas
/
Aterosclerosis
/
Mapas de Interacción de Proteínas
/
Genética
/
Métodos
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Biomedical Engineering
Año:
2015
Tipo del documento:
Artículo
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