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Preparation of transfersomes of vincristine sulfate and study on its prcutaneous penetration / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 900-903, 2005.
Artículo en Chino | WPRIM | ID: wpr-358061
ABSTRACT
<p><b>OBJECTIVE</b>To select the best preparation method of vincristine transfersomes (VCR-T) and predict its possibility of being a new formulation of VCR.</p><p><b>METHOD</b>Orthogonal design was used to optimize the preparation methods on the basis of single factor pretests; and the permeation tests in vitro were performed in modified Franz diffusion cells.</p><p><b>RESULT</b>The optimum formula was pH was equal to 7.3, the ratio of lecithin to sodium deoxycholate is 70/20, the weight of VCR is 10 mg, hydrating time is 30 minutes. The optimized solution was light yellow and transparent colloid solution. The VCR-T are spherical and smooth with average diameters of 94 nm and an encapsulation ratio of 90%. The test in vitro showed that VCR-T could permeat through mouse skin at zero rate with the cumulative penetrating quality amounting to 63.8%.</p><p><b>CONCLUSION</b>Transfersomes may become a promising carrier of VCR for clinic use.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Tamaño de la Partícula / Fosfatidilcolinas / Absorción Cutánea / Vincristina / Administración Cutánea / Portadores de Fármacos / Farmacocinética / Tecnología Farmacéutica / Ácido Desoxicólico / Concentración de Iones de Hidrógeno Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Chino Revista: China Journal of Chinese Materia Medica Año: 2005 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Tamaño de la Partícula / Fosfatidilcolinas / Absorción Cutánea / Vincristina / Administración Cutánea / Portadores de Fármacos / Farmacocinética / Tecnología Farmacéutica / Ácido Desoxicólico / Concentración de Iones de Hidrógeno Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Chino Revista: China Journal of Chinese Materia Medica Año: 2005 Tipo del documento: Artículo