Comparative study of chitosan/fibroin-hydroxyapatite and collagen membranes for guided bone regeneration in rat calvarial defects: micro-computed tomography analysis / 国际口腔科学杂志·英文版
International Journal of Oral Science
;
(4): 87-93, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-358139
ABSTRACT
This study aimed to utilize micro-computed tomography (micro-CT) analysis to compare new bone formation in rat calvarial defects using chitosan/fibroin-hydroxyapatite (CFB-HAP) or collagen (Bio-Gide) membranes. Fifty-four (54) rats were studied. A circular bony defect (8 mm diameter) was formed in the centre of the calvaria using a trephine bur. The CFB-HAP membrane was prepared by thermally induced phase separation. In the experimental group (n=18), the CFB-HAP membrane was used to cover the bony defect, and in the control group (n=18), a resorbable collagen membrane (Bio-Gide) was used. In the negative control group (n=18), no membrane was used. In each group, six animals were euthanized at 2, 4 and 8 weeks after surgery. The specimens were then analysed using micro-CT. There were significant differences in bone volume (BV) and bone mineral density (BMD) (P<0.05) between the negative control group and the membrane groups. However, there were no significant differences between the CFB-HAP group and the collagen group. We concluded that the CFB-HAP membrane has significant potential as a guided bone regeneration (GBR) membrane.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Cráneo
/
Anomalías Congénitas
/
Regeneración Ósea
/
Química
/
Colágeno
/
Ratas Sprague-Dawley
/
Quitosano
/
Microtomografía por Rayos X
/
Fibroínas
/
Métodos
Límite:
Animales
Idioma:
Inglés
Revista:
International Journal of Oral Science
Año:
2014
Tipo del documento:
Artículo
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