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The relationship between 99mTc-MIBI scintimammography of breast cancer and multidrug-resistant proteins / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 606-608, 2005.
Article en Zh | WPRIM | ID: wpr-358558
Biblioteca responsable: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the relationship between the clearance rate of technetium-99m methoxyisobutylisonitrile ((99m)Tc-MIBI) in scintimammography and multidrug-resistant proteins expression in breast cancer tissues.</p><p><b>METHODS</b>Seventy-six patients with breast cancer underwent (99m)Tc-MIBI scintimammography before treatment, and static planar images were taken at 10 min and 180 min after scintimammography. The clearance rate of (99m)Tc-MIBI was calculated in each patient. Immunohistochemical analysis was performed on pathological specimens of the 76 breast tumors to determine the expression of P-glycoprotein (P-gp), glutathione S-transferase Pi (GST-pi) and topoisomerase II (Topo II).</p><p><b>RESULTS</b>The clearance rate was significantly higher in 36 patients with positive P-gp expression when compared with that in 40 patients with negative P-gp expression. There was no significant relationship between GST-pi, Topo II and the clearance rate of (99m)Tc-MIBI.</p><p><b>CONCLUSION</b>The clearance rate of (99m)Tc-MIBI in breast imaging may be used to evaluate the P-gp level in breast cancers.</p>
Asunto(s)
Texto completo: 1 Índice: WPRIM Asunto principal: Neoplasias de la Mama / Diagnóstico por Imagen / Inmunohistoquímica / Cintigrafía / Química / Tecnecio Tc 99m Sestamibi / Carcinoma Ductal de Mama / ADN-Topoisomerasas de Tipo II / Resistencia a Múltiples Medicamentos / Radiofármacos Tipo de estudio: Diagnostic_studies Límite: Adult / Aged / Female / Humans Idioma: Zh Revista: Chinese Journal of Oncology Año: 2005 Tipo del documento: Article
Texto completo: 1 Índice: WPRIM Asunto principal: Neoplasias de la Mama / Diagnóstico por Imagen / Inmunohistoquímica / Cintigrafía / Química / Tecnecio Tc 99m Sestamibi / Carcinoma Ductal de Mama / ADN-Topoisomerasas de Tipo II / Resistencia a Múltiples Medicamentos / Radiofármacos Tipo de estudio: Diagnostic_studies Límite: Adult / Aged / Female / Humans Idioma: Zh Revista: Chinese Journal of Oncology Año: 2005 Tipo del documento: Article