The relationship between 99mTc-MIBI scintimammography of breast cancer and multidrug-resistant proteins / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 606-608, 2005.
Article
en Zh
| WPRIM
| ID: wpr-358558
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the relationship between the clearance rate of technetium-99m methoxyisobutylisonitrile ((99m)Tc-MIBI) in scintimammography and multidrug-resistant proteins expression in breast cancer tissues.</p><p><b>METHODS</b>Seventy-six patients with breast cancer underwent (99m)Tc-MIBI scintimammography before treatment, and static planar images were taken at 10 min and 180 min after scintimammography. The clearance rate of (99m)Tc-MIBI was calculated in each patient. Immunohistochemical analysis was performed on pathological specimens of the 76 breast tumors to determine the expression of P-glycoprotein (P-gp), glutathione S-transferase Pi (GST-pi) and topoisomerase II (Topo II).</p><p><b>RESULTS</b>The clearance rate was significantly higher in 36 patients with positive P-gp expression when compared with that in 40 patients with negative P-gp expression. There was no significant relationship between GST-pi, Topo II and the clearance rate of (99m)Tc-MIBI.</p><p><b>CONCLUSION</b>The clearance rate of (99m)Tc-MIBI in breast imaging may be used to evaluate the P-gp level in breast cancers.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Neoplasias de la Mama
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Diagnóstico por Imagen
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Inmunohistoquímica
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Cintigrafía
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Química
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Tecnecio Tc 99m Sestamibi
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Carcinoma Ductal de Mama
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ADN-Topoisomerasas de Tipo II
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Resistencia a Múltiples Medicamentos
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Radiofármacos
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
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Aged
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Female
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Humans
Idioma:
Zh
Revista:
Chinese Journal of Oncology
Año:
2005
Tipo del documento:
Article