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Long-term results of 84 surgically treated patients with extrahepatic bile duct carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 554-556, 2005.
Artículo en Chino | WPRIM | ID: wpr-358572
ABSTRACT
<p><b>OBJECTIVE</b>Extrahepatic bile duct carcinoma is a rare but dismal malignacy. This study is conducted to show retrospective review and analysis of the correlation between the prognosis and different treatment modalities.</p><p><b>METHODS</b>The data of 84 such patients treated by different modalities from January, 1992 to July, 2000 were retrospectively reviewed and analyzed using SPSS 10.0 statistical package. The survivals were estimated by the Kaplan-Meier method and the difference among groups was tested by the log-rank test. The prognostic factors were determined by Cox multivariate analysis.</p><p><b>RESULTS</b>Of the 84 patients, 33 had complete resection, 19 palliative resection, 12 exploration alone, and the remaining 20 were treated by chemotherapy and/or radiotherapy. The mean follow-up time was 592 days. The overall 5-year survival rate was 13.1%. The 1-, 3- and 5-year survival rate following complete resection was 76.8%, 52.6% and 30.5% respectively, which was significantly higher than those of palliative surgery or chemotherapy/radiotherapy (P < 0.01). Multivariate analysis revealed that lymph node status (P = 0), histopathological grade (P = 0.001) and distant metastasis (P = 0.002) were significant high risk factors.</p><p><b>CONCLUSION</b>The prognosis of extrahepatic bile duct carcinoma remains poor even after complete resection as shown to have a 5-year survival of 30.5%. More effective adjuvant therapy is needed. Extended resection may be helpful in improving the prognosis for carefully selected patients. Early diagnosis and early treatment is still the key to improve the long-term survival of extrahepatic bile duct carcinoma.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pronóstico / Cirugía General / Neoplasias de los Conductos Biliares / Procedimientos Quirúrgicos del Sistema Biliar / Adenocarcinoma / Análisis de Supervivencia / Estudios Retrospectivos / Estudios de Seguimiento / Mortalidad / Resultado del Tratamiento Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo / Estudio de tamizaje Límite: Adulto / Anciano / Aged80 / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Oncology Año: 2005 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pronóstico / Cirugía General / Neoplasias de los Conductos Biliares / Procedimientos Quirúrgicos del Sistema Biliar / Adenocarcinoma / Análisis de Supervivencia / Estudios Retrospectivos / Estudios de Seguimiento / Mortalidad / Resultado del Tratamiento Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo / Estudio de tamizaje Límite: Adulto / Anciano / Aged80 / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Oncology Año: 2005 Tipo del documento: Artículo