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Association of p53 codon 72 polymorphism with liver metastases of colorectal cancers positive for p53 overexpression / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B ; (12): 847-852, 2008.
Artículo en Inglés | WPRIM | ID: wpr-359351
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the association between p53 codon 72 polymorphism (R72P) and the risk of colorectal liver metastases.</p><p><b>METHODS</b>The p53 R72P genotype was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 78 consecutive colorectal cancer patients with liver metastases and 214 age- and sex-matched cases with nonmetastatic colorectal cancer.</p><p><b>RESULTS</b>The R allele of the p53 R72P polymorphism was more frequently found in metastatic cases than in nonmetastatic cases (P=0.075). Carriers of the 72R allele had a 2.25-fold (95% CI (confidence interval)=1.05 to approximately 4.83) increased risk of liver metastases. On the stratification analysis, 72R-carrying genotype conferred a 3.46-fold (95% CI=1.02 to approximately 11.72) and a 1.05-fold (95% CI=0.36 to approximately 3.08) increased risk of liver metastases for p53 overexpression-positive and negative colorectal cancers, respectively.</p><p><b>CONCLUSION</b>These results demonstrate for the first time that the 72R allele of the p53 polymorphism has an increased risk for liver metastases in colorectal cancers positive for p53 overexpression.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Sangre / Polimorfismo de Longitud del Fragmento de Restricción / ADN de Neoplasias / Neoplasias Colorrectales / Adenocarcinoma / Estudios de Casos y Controles / Modelos Logísticos / Reacción en Cadena de la Polimerasa / Análisis Multivariante Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Femenino / Humanos / Masculino Idioma: Inglés Revista: Journal of Zhejiang University. Science. B Año: 2008 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Sangre / Polimorfismo de Longitud del Fragmento de Restricción / ADN de Neoplasias / Neoplasias Colorrectales / Adenocarcinoma / Estudios de Casos y Controles / Modelos Logísticos / Reacción en Cadena de la Polimerasa / Análisis Multivariante Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Femenino / Humanos / Masculino Idioma: Inglés Revista: Journal of Zhejiang University. Science. B Año: 2008 Tipo del documento: Artículo