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Biological transport of tetracycline hydrochloride by human periodontal ligament fibroblasts / 中华口腔医学杂志
Chinese Journal of Stomatology ; (12): 57-58, 2008.
Artículo en Chino | WPRIM | ID: wpr-359637
ABSTRACT
<p><b>OBJECTIVE</b>To investigate biological transport of tetracycline hydrochloride by human periodontal ligament fibroblasts (HPDLF) for verifying the hypothesis of delivering medicine to the periodontium and whole body through the root canal.</p><p><b>METHODS</b>HPDLF and MC3T3-E1 cells were incubated in antibiotics solutions. The intracellular antibiotics contents were measured by high performance liquid chromatography (HPLC) and the cell total protein was measured by bradford protein assay.</p><p><b>RESULTS</b>The intracellular contents increased with incubation time. The extracellular medicine concentration had effect on the intracellular contents.</p><p><b>CONCLUSIONS</b>Tetracycline hydrochloride can be transported into HPDLF with incubation and this transport is time-dependent and concentration-dependent.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Ligamento Periodontal / Tetraciclina / Transporte Biológico / Farmacocinética / Células Cultivadas / Fibroblastos / Metabolismo / Antibacterianos Límite: Humanos Idioma: Chino Revista: Chinese Journal of Stomatology Año: 2008 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Ligamento Periodontal / Tetraciclina / Transporte Biológico / Farmacocinética / Células Cultivadas / Fibroblastos / Metabolismo / Antibacterianos Límite: Humanos Idioma: Chino Revista: Chinese Journal of Stomatology Año: 2008 Tipo del documento: Artículo