Expression of vascular endothelial growth factor, vascular endothelial growth factor receptor-3 and nm23-H1 in oral squamous cell carcinoma / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 681-683, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-359660
ABSTRACT
<p><b>OBJECTIVE</b>To explore the role of vascular endothelial growth factor C (VEGF-C), VEGFR-3 and nm23-H(1) in lymphatic metastasis of oral squamous cell carcinoma (OSCC).</p><p><b>METHODS</b>The expression of VEGF-C, VEGFR-3 and nm23-H(1) were examined by immunohistochemical SP method. The lymphatic vessels density (LVD) in tumors was counted and analyzed with clinicopathologic parameters.</p><p><b>RESULTS</b>VEGF-C, LVD and nm23-H(1) expressions were significantly different between OSCC and benign and precancerous lesions (P < 0.05). VEGF-C was correlated with lymph node metastasis and LVD (P < 0.01). nm23-H(1) was related to clinical stage, histological grade and lymphatic metastasis (P < 0.05).</p><p><b>CONCLUSIONS</b>The high expressions of VEGF-C/VEGFR-3 and inactivation of nm23-H(1) may play an important role in lymphatic metastasis in OSCC.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Neoplasias de la Boca
/
Carcinoma de Células Escamosas
/
Receptor 3 de Factores de Crecimiento Endotelial Vascular
/
Factor C de Crecimiento Endotelial Vascular
/
Nucleósido Difosfato Quinasas NM23
/
Metástasis Linfática
/
Metabolismo
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Stomatology
Año:
2007
Tipo del documento:
Artículo
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