Porphyromonas gingivalis vesicle induced cellular inflammatory responses of gingival epithelial cells in vitro / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 564-567, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-359693
ABSTRACT
<p><b>OBJECTIVE</b>To establish the model of cellular inflammatory responses of gingival epithelial cells in vitro induced by Porphyromonas gingivalis vesicle and to probe into the pathogenesis of Porphyromonas gingivalis in periodontitis.</p><p><b>METHODS</b>The effect of Porphyromonas gingivalis vesicle on prostaglandin E(2) (PGE(2)) production of gingival epithelial cells was detected by ELISA and the effects of Porphyromonas gingivalis vesicle on cyclooxygenase-2 (COX-2), interleukin (IL)-6 and IL-8 mRNA expression in gingival epithelial cells were determined by Real-time reverse transcription-polymerase chain reaction (RT-PCR).</p><p><b>RESULTS</b>Porphyromonas gingivalis vesicle dose-dependently induced PGE(2) production and up-regulated COX-2, IL-6 and IL-8 mRNA expression in gingival epithelial cells significantly.</p><p><b>CONCLUSIONS</b>Cellular inflammatory responses of gingival epithelial cells induced by Porphyromonas gingivalis vesicle may contribute to the initiation and progression of periodontitis.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Virulencia
/
Adhesión Bacteriana
/
Dinoprostona
/
Células Cultivadas
/
Interleucina-8
/
Interleucina-6
/
Porphyromonas gingivalis
/
Alergia e Inmunología
/
Células Epiteliales
/
Ciclooxigenasa 2
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Stomatology
Año:
2007
Tipo del documento:
Artículo
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