Ex vivo antioxidant effects of D-004, a lipid extract from Roystonea regia fruits, on rat prostate tissue / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 659-666, 2008.
Artículo
en Inglés
| WPRIM
| ID: wpr-359924
ABSTRACT
<p><b>AIM</b>To investigate whether oral treatment with D-004, a lipid extract of the Cuban royal palm fruit, produces antioxidant effects in the prostate tissue of normal and testosterone (T)-treated rats.</p><p><b>METHODS</b>In our first experiment, normal rats were distributed into five groups one group treated with the vehicle and four groups treated with D-004 (100, 200, 400 or 800 mg/kg). In our second experiment, rats were randomized into five groups a negative control group and four T-injected groups. The latter were comprised of a positive control group treated with the vehicle, and three groups treated with D-004 (200, 400 or 800 mg/kg).</p><p><b>RESULTS</b>In normal rats, D-004 (100-800 mg/kg) inhibited significantly and dose-dependently iron-initiated malondialdehyde (MDA) accumulation in prostate homogenates (35.7%-80.0%) vs the controls. D-004 (200-800 mg/kg) significantly reduced baseline MDA and carbonyl groups in prostate homogenates of normal rats to approximately 80% and 50%, respectively, and totally (100%) in T-treated rats.</p><p><b>CONCLUSION</b>Oral treatment with D-004 reduced MDA and carbonyl groups dose-dependently and markedly in normal and T-injected rats. These findings show that D-004 given at doses effective to prevent prostate hyperplasia also produces antioxidant effects in the prostate tissue.</p>
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Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Próstata
/
Hiperplasia Prostática
/
Extractos Vegetales
/
Administración Oral
/
Ratas Wistar
/
Relación Dosis-Respuesta a Droga
/
Malondialdehído
/
Metabolismo
/
Antioxidantes
Límite:
Animales
Idioma:
Inglés
Revista:
Asian Journal of Andrology
Año:
2008
Tipo del documento:
Artículo
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