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Lipid peroxidation and ultrastructural modifications in brain after perinatal exposure to lead and/or cadmium in rat pups / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences ; (12): 423-429, 2009.
Artículo en Inglés | WPRIM | ID: wpr-360644
ABSTRACT
<p><b>OBJECTIVE</b>To assess lipid peroxidation and ultrastructural modifications in rat brains following perinatal exposure to lead (Pb) and/or cadmium (Cd).</p><p><b>METHODS</b>Female rats were divided into four groups control group, Pb (300 mg/L) group, Cd group (10 mg/L) and Pb+Cd (300 mg/L, 10 mg/L) group. The compounds were delivered in the drinking water throughout pregnancy and lactation.</p><p><b>RESULTS</b>The levels of compounds in blood and brain of the Pb+Cd group were similar to those of other groups, but the effects of Pb+Cd on pups' body and brain weights were higher than on other compounds. Electron microscopy revealed that Pb and Cd had effects on mitochondrial swelling, disruption and cristae loss, Nissl body dissolution, degenerated organelles and vacuoles, cytomembrane disappearance, and nuclear chromoplasm concentration. The activity of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT), acetylcholinesterase (AChE) was decreased, whereas the activity of maleic dialdehyde (MDA) was increased.</p><p><b>CONCLUSION</b>Perinatal exposure to low doses of Pb and Cd can produce alterations in lipid peroxidation and ultrastructural modifications in rat brains, and exposure to both metals can result in greater damages.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Efectos Tardíos de la Exposición Prenatal / Encéfalo / Cadmio / Agua / Peroxidación de Lípido / Contaminantes Ambientales / Toxicidad / Plomo / Malondialdehído / Metabolismo Límite: Animales / Embarazo Idioma: Inglés Revista: Biomedical and Environmental Sciences Año: 2009 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Efectos Tardíos de la Exposición Prenatal / Encéfalo / Cadmio / Agua / Peroxidación de Lípido / Contaminantes Ambientales / Toxicidad / Plomo / Malondialdehído / Metabolismo Límite: Animales / Embarazo Idioma: Inglés Revista: Biomedical and Environmental Sciences Año: 2009 Tipo del documento: Artículo