Analysis of rejection after simultaneous pancreas-kidney transplantation / 中华外科杂志
Chinese Journal of Surgery
;
(12): 926-928, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-360956
ABSTRACT
<p><b>OBJECTIVE</b>To explore methods of preventing and reversing rejection after simultaneous pancreas-kidney transplantation (SPK).</p><p><b>METHODS</b>Seventeen patients performed SPK operation from Sep, 1999 to Sep, 2003 were reviewed retrospectively. Immunosuppression was achieved by triple regimen consisting of cyclosporine, mycophenolate mofetil (MMF)/azathioprine and steroid. 2 patients were treated with Dalizumab, the other three patients used OKT3 as immune induction.</p><p><b>RESULTS</b>1 patient experienced the accelerated rejection, the pancreas and kidney grafts were resected because of failure of conservative therapy. 8 patients experienced renal acute rejection, 2 cases suffered from pancreas acute rejection at the same time. All these patients received daily high dose pulse steroid for 3 days. OKT3 was administered in 2 patients with steroid resistance rejection. All the grafts were successfully rescued.</p><p><b>CONCLUSIONS</b>Reasonable application of immunosuppression after SPK operation and adoption of systemic measures which can reduce sensitivity of high risk receptor before SPK operation are the effective methods of preventing and treating rejection.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Cirugía General
/
Azatioprina
/
Trasplante Homólogo
/
Prednisolona
/
Administración Oral
/
Estudios Retrospectivos
/
Trasplante de Riñón
/
Trasplante de Páncreas
/
Ciclosporina
/
Nefropatías Diabéticas
Tipo de estudio:
Estudio observacional
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Surgery
Año:
2004
Tipo del documento:
Artículo
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