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Genetic Polymorphisms of \it{CYP2A6} and \it{CYP2E1} with Tobacco Smoking is not Associated with Risk of Urothelial Cancer
Article en Ja | WPRIM | ID: wpr-361513
Biblioteca responsable: WPRO
ABSTRACT
Objectives: To elucidate the association between genetic polymorphisms of CYP2A6 and CYP2E1 and urothelial cancer susceptibility. Methods: A total of 137 Japanese patients with urothelial cancer and 217 Japanese healthy controls, frequency-matched for age and gender, were selected. The polymorphisms of CYP2A6 and CYP2E1 were analyzed by PCR-RFLP, and cigarette smoking histories were obtained through interviews. Results: The frequency of CYP2A6 homozygote deletion genotype was 2.9% in the patients, compared with 3.2% in the controls (OR=0.84, 95% CI 0.24−2.96). The frequencies of CYP2E1 C1/c2 and C2/c2 were 27.7% and 4.4% in the patients, compared with 35.5% and 6.0% in the controls (OR=0.68, 95% CI 0.42 −1.09, OR=0.67, 95% CI 0.24−1.84, respectively). No statistically significant differences were observed when the CYP2A6 homozygote deletion genotype and the CYP2E1 genotypes were examined relative to smoking status. Conclusions: Our data indicate that neither a relationship between genetically impaired nitrosamine metabolism and tobacco-smoking consumption, nor urothelial cancer risk related to the CYP2A6 deletion genotype and CYP2E1 Rsa I genotype was found in Japanese population.
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Texto completo: 1 Índice: WPRIM Asunto principal: Citocromo P-450 CYP2E1 / Genotipo / Neoplasias Tipo de estudio: Etiology_studies Idioma: Ja Revista: Environmental Health and Preventive Medicine Año: 2002 Tipo del documento: Article
Texto completo: 1 Índice: WPRIM Asunto principal: Citocromo P-450 CYP2E1 / Genotipo / Neoplasias Tipo de estudio: Etiology_studies Idioma: Ja Revista: Environmental Health and Preventive Medicine Año: 2002 Tipo del documento: Article