Determination of the Platelet Activating Factor in Silicotic Patients and its Effect on Fibroblasts
Environmental Health and Preventive Medicine
;
: 134-137, 2000.
Artículo
en Japonés
| WPRIM
| ID: wpr-361606
ABSTRACT
Platelet-activation factor (PAF), one of the potent proinflammatory mediators, is produced from a large range of cells, including polymorphonuclear neutrophils, monocytes, and natural killer cells. To study the role of PAF in the pathogenesis of silicosis, we determined the PAF in silicotic patients and in healthy persons. The results showed that the concentration of PAF in the plasma of silicotic patients was significantly higher than that of healthy persons. Our in vitro experimental results showed that the total numbers of fibroblasts were markedly raised with added PAF from 0 to 1 μ g/ml. Adding 1 μ g/ml PAF significantly increased the total numbers of fibroblasts after culture for 48, 72, 96 hrs. Therefore, we suggest that PAF be possibly involved in the pathogenesis of silicosis. However, the mechanism remains to be further elucidated.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Factor de Activación Plaquetaria
Idioma:
Japonés
Revista:
Environmental Health and Preventive Medicine
Año:
2000
Tipo del documento:
Artículo
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