Mitochondrial DNA Aberrations of Bone Marrow Cells from Patients with Aplastic Anemia
Journal of Korean Medical Science
;
: 1062-1067, 2008.
Artículo
en Inglés
| WPRIM
| ID: wpr-36260
ABSTRACT
This study was undertaken primarily to test the hypothesis that mitochondrial DNA (mtDNA) mutations may be associated with aplastic anemia. Complete mtDNA nucleotide sequence was analyzed in nine and eight bone marrow specimens from Korean patients with aplastic anemia and healthy individuals, respectively. We found a large number of polymorphisms as well as apparent new mutations in both patients and controls throughout the entire mtDNA genome; 12 mutations harbored amino acid changes in patients and none of the mutations in controls produced amino acid changes. There were heteroplasmic mutations and more nonsynonymous mtDNA changes observed in patients, so the mean number of mtDNA aberrations of bone marrow cells showed statistically significant difference overall between patients (mean=25.6) and controls (mean=12.8) (p=0.019). Our data may support an association of mtDNA aberrations with aplastic anemia.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
ADN Mitocondrial
/
Células de la Médula Ósea
/
Análisis Mutacional de ADN
/
Interpretación Estadística de Datos
/
Análisis de Secuencia de ADN
/
Mutación Puntual
/
Eliminación de Gen
/
Sustitución de Aminoácidos
/
Anemia Aplásica
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
2008
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS