Effects of Electrolyte Composition and Prostaglandin E₁ of Extra-Cellular Fluid on Coronary Artery Contraction / 日本心臓血管外科学会雑誌

ABSTRACT

We studied the effects of the electrolyte composition (K, Ca, Na) and prostaglandin E₁ of the extra-cellular fluid on the tension development of isolated canine coronary arterial strips. In 20mEq/<i>l</i> potassium solution, 4.7mEq/<i>l</i> calcium produced coronary artery contraction. This Ca-induced contraction was partially inhibited dose-dependently (between 10^-15M and 10^-12M) by prostaglandin E₁. Above 10^-11M, intensity of the inhibition did not change. In the presence of 20mEq/<i>l</i> potassium, the reduction of sodium concentration to 12mEq/<i>l</i> increased the tension of coronary artery. Prostaglandin E₁ did not affect this tension development. After 5min perfusion of prostaglandin E₁, Ca-induced contraction was not inhibited. It is concluded that low calcium, high sodium cardioplegic solution may relax the canine coronary artery. Addition of prostaglandin E₁ to cardioplegic solution may reduce the coronary artery contraction partially.