Estimation of Thrombus Formation in Aneurysms by 111In Labeled Platelet Scintigraphy, EPA and FDP-E / 日本心臓血管外科学会雑誌

ABSTRACT

Intra-aortic-aneurysmal thrombi sometimes cause severe complications, such as distal arterial thromboembolism and consumption coaguropathy, significantly affecting the prognosis. Such thrombi can be easily detected by CT-scan, Ultrasound and MRI, but these imaging techniques cannot indicate thombotic activity. The radioactivity of ¹¹¹In labeled platelet scintigraphy (platelet scintigraphy) can reflect thrombotic activity. We performed platelet scintigraphy in 13 true aortic aneurysms (TA), 17 dissecting aortic aneurysms (DA) and 11 postoperative cases of dissecting aortic aneurysms (PO) and the results were compared with the values of fibrino-petide-A (FPA) and FDP-E in blood. In cases of the TA, the result of platelet scintigraphy showed the radioactivity of abdominal aortic aneurysms (AAA) is stronger than that of thoracic aortic aneurysms (TAA). In the cases of DA, the group of thrombotic dissection showed no RI deposit. Acute cases showed strong RI deposit with gradual reduction. Two cases of PO, in which anti-coagulant therapy had been performed showed no RI deposit. Concerning the results of FPA and FDP-E, the values for AAA were higher than those of TAA, and in cases of DA, acute cases showed a high value, with gradual reduction, while two PO cases with anti-coagulant therapy showed low values. No significant correlation was found between the value of FPA and FDP-E. On the other hand, the values of FPA and FDP-E significantly correlated to radioactivity of platelet scintigraphy. The higher was the value of FPA and FDP-E, the stronger was the radioactivity. The values of FPA and FDP-E of the strong radioactivity group were significantly higher than these of the weak radioactivity group. Platelet scintigraphy and measurement the value of FPA and FDP-E are effective to estimate intra-aortic-aneurysmal thrombotic activity, and useful to anticipate complications and evaluate prognosis.