The Immediate Effect of Kakkon-to-ka-senkyu-shin'i (Ge-gen-tang-jia-chuan-xiong-xin-yi) on Nasal Obstruction Evaluated by Acoustic Rhinometry / 日本東洋医学雑誌

ABSTRACT

The author evaluated the immediate effect of a single dose of Kakkon-to-ka-senkyu-shin'i on nasal obstructin in a 26-year-old male patient with exacerbated nasal allergy symptoms. A 100mm-linear visual analogue scale (VAS 0=complete nasal patency and 100=complete nasal obstruction while breathing through both nostrils with the mouth closed) was used for subjective measurement of nasal sensation of airflow. At the same time, acoustic rhinometry was performed to objectively measure the minimum cross-sectional area (MCA) and cavity volume (NCV) of the nose.<br>1) The VAS score decreased linearly from 47 to 43 for the first 70 minutes after the medication was administered. During this period, the linear regression was significant (p<0.05). After the first 70 minutes, the VAS score started to increase.<br>2) Right+left MCA and right+left NCV increased linearly in the same period, 0.24cm²to 0.39cm² and 11.47cm³ to 13.74cm³, respectively. These slopes were also significant by linear regression analysis (p<0.05. respectively). Both of these values started decreasing after this period. These findings were in close agreement with those obtained in the simultaneous VAS study.<br>In conclusion, Kakkon-to-ka-senkyu-shin'i apparently produced an immediate effect on allergy-induced nasal obstruction in a patient who recovered his nasal patency within an hour after administration, although the effect was not long-lasting.