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Lycopene supplementation suppresses oxidative stress induced by a high fat diet in gerbils
Nutrition Research and Practice ; : 26-33, 2013.
Artículo en Inglés | WPRIM | ID: wpr-36888
ABSTRACT
The effect of lycopene supplementation on the antioxidant system was investigated by analyzing lipid peroxide levels, glutathione contents, and antioxidant enzyme activities in Mongolian gerbils fed a high fat diet. Gerbils were fed on each experimental diet for 6 weeks; normal diet (NC), normal diet with 0.05% lycopene (NL), high fat diet (HF), and a high fat diet with 0.05% lycopene (HFL). Dietary supplementation of lycopene increased hepatic lycopene level in gerbils fed a normal or high fat diet (P < 0.05). Liver and erythrocyte concentrations of lipid peroxide increased in gerbils fed a high fat diet, whereas lycopene supplementation decreased liver and erythrocyte concentrations of lipid peroxide (P < 0.05). Hepatic total glutathione content was higher in the NL group than that in the NC group (P < 0.05). Total antioxidant status in plasma increased following lycopene supplementation compared with that of the non-lycopene supplemented groups (P < 0.05). Hepatic catalase activity increased following dietary lycopene supplementation (P < 0.05). Superoxide dismutase activity in liver remained unchanged with lycopene supplementation, but erythrocyte superoxide dismutase activity increased in NL group compared with NC group (P < 0.05). Glutathione-S-transferase activity increased in the NL group compared to NC group (P < 0.05). Liver and erythrocyte glutathione peroxidase activity increased significantly in the NL group compared to that in the HF group (P < 0.05). Liver glutathione reductase activity was higher in the NL group than that in the NC group (P < 0.05). These results suggest that lycopene supplementation may be efficient for preventing chronic diseases induced by oxidative stress related to high fat diet.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Plasma / Superóxido Dismutasa / Carotenoides / Catalasa / Enfermedad Crónica / Gerbillinae / Estrés Oxidativo / Suplementos Dietéticos / Dieta / Eritrocitos Idioma: Inglés Revista: Nutrition Research and Practice Año: 2013 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Plasma / Superóxido Dismutasa / Carotenoides / Catalasa / Enfermedad Crónica / Gerbillinae / Estrés Oxidativo / Suplementos Dietéticos / Dieta / Eritrocitos Idioma: Inglés Revista: Nutrition Research and Practice Año: 2013 Tipo del documento: Artículo