Microneedle patches for vaccine delivery
Clinical and Experimental Vaccine Research
;
: 42-49, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-36954
ABSTRACT
In today's medical industry, the range of vaccines that exist for administration in humans represents an eclectic variety of forms and immunologic mechanisms. Namely, these are the live attenuated viruses, inactivated viruses, subunit proteins, and virus-like particles for treating virus-caused diseases, as well as the bacterial-based polysaccharide, protein, and conjugated vaccines. Currently, a new approach to vaccination is being investigated with the concept of DNA vaccines. As an alternative delivery route to enhance the vaccination efficacy, microneedles have been devised to target the rich network of immunologic antigen-presenting cells in the dermis and epidermis layers under the skin. Numerous studies have outlined the parameters of microneedle delivery of a wide range of vaccines, revealing comparable or higher immunogenicity to conventional intramuscular routes, overall level of stability, and dose-sparing advantages. Furthermore, recent mechanism studies have begun to successfully elucidate the biological mechanisms behind microneedle vaccination. This paper describes the current status of microneedle vaccine research.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Piel
/
Vacunas Bacterianas
/
Vacunas
/
Vacunación
/
Vacunas de ADN
/
Dermis
/
Epidermis
/
Células Presentadoras de Antígenos
Límite:
Humanos
Idioma:
Inglés
Revista:
Clinical and Experimental Vaccine Research
Año:
2014
Tipo del documento:
Artículo
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