Recovery of Lymphocyte Subpopulations in Children with Hematologic Malignancies after Completion of Chemotherapy / 대한소아혈액종양학회지
Korean Journal of Pediatric Hematology-Oncology
;
: 67-76, 2001.
Artículo
en Coreano
| WPRIM
| ID: wpr-37334
ABSTRACT
PURPOSE:
Children with cancer are immunosuppressed as a result of the underlying malignancies and their treatment. The aim of this study was to investigate immunophenotypic recovery of lymphocyte populations following completion of treatment in children with hematologic malignancies.METHODS:
Thirty eight patients were followed up to the Department of Pediatrics, Chonnam National University Hospital from Jan. 1995 to Nov. 1999. Using flow cytometry with fluorescein-conjugated monoclonal antibodies of lymphocytes, T-, B-, and Natural killer (NK) cells and CD4/CD8 ratio were enumerated in 38 patients {acute lymphoblastic leukemia (ALL), 19; acute myeloid leukemia (AML), 14; non-Hodgkin's lymphoma (NHL), 5} from 3 months after completion of therapy and every 3 months thereafter over 2 years. The recovery rates of each parameters were compared according to diseases, age and gender.RESULTS:
Absolute lymphocyte count was achieved in 50.0% (19/38) and 73.7% (28/38) of patients at 3 and 12 months after completion of therapy, respectively. Absolute B cell counts as well as the proportion of patients with normal B cell counts were low in NHL than in AML (298+/-250/microliter vs 594+/-356/microliter; P=0.037) at 12 months. T cell recovery tended to be faster in ALL, followed by AML and NHL. NK cell recovery was comparable among 3 disease subgroups. CD4/CD8 ratio was significantly lower in NHL (0.14+/-0.16) than ALL (0.79+/-0.33; P=0.018) at 3 months. CD4/CD8 ratio of NHL (0.41+/-0.14) was lower than ALL (0.79+/-0.29; P=0.033) at 6 months. Differences of CD4/CD8 ratio among the three disease groups were not statistically significant after 9 months. CD4/CD8 ratio was inverted in 22 of 38 (57.9%) patients even after 24 months of therapy. At 12 months higher proportion of male (47.4%, 9/19) achieved a normal CD4/CD8 ratio than that of female (15.8%, 3/19; P=0.036). Age did not make any differences in the recovery.CONCLUSION:
Children with hematologic malignancies have persistent abnormalities of lymphocyte subpopulations often after 2 years following completion of chemotherapy. These results suggest that immunologic assessment are required and that preventive measures for infections might be required for more than 2 years after chemotherapy in some patients. Duration of follow-up observation should be differed according to underlying malignancies and their treatment intensity.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pediatría
/
Linfoma no Hodgkin
/
Células Asesinas Naturales
/
Linfocitos
/
Leucemia Mieloide Aguda
/
Recuento de Células
/
Estudios de Seguimiento
/
Subgrupos Linfocitarios
/
Recuento de Linfocitos
/
Neoplasias Hematológicas
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Niño
/
Femenino
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Pediatric Hematology-Oncology
Año:
2001
Tipo del documento:
Artículo
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