<b>Indicators for Treatment of Coldness with Tokishakuyakusan and Kamishoyosan </b> / 日本東洋医学雑誌

ABSTRACT

<i><b>Objectives </b></i>: We evaluated the efficacy of tokishakuyakusan and kamishoyosan for patients who complained of feeling cold, and identified key symptoms that would predict positive treatment outcomes for coldness with these medicines.<br><i><b>Design </b></i>: A retrospective cohort study<br><i><b>Subjects and Methods </b></i>: The subjects were 188 patients who reported feeling cold. They were treated with tokishakuyakusan or kamishoyosan according to their <i>Sho </i>for more than one month. The relationships between improvement of cold sensation and 62 factors, including other symptoms noted at the first medical examination, were evaluated by means of cross-sectional analysis, followed by logistic regression.<br><i><b>Results </b></i>: The factors of coldness of the abdomen (odds ratio, 5.0), vertigo (7.7), dimness of sight (16) and blushing (5.6), without anger (0.11) or tinnitus (0.025), were found to be predictors of a positive effect with tokishakuyakusan treatment (p < 0.001). The factors of hot flushes (14), without coldness of the whole body (0.099), and faint feeling (0.21) were significant for kamishoyosan (p < 0.001). This suggests that kamishoyosan can improve subjective coldness of the extremities (AIC -8.64), especially of the legs (-2.23).<br><i><b>Conclusions </b></i>: Coldness in the abdomen was an important indicator for treatment with tokishakuyakusan, while coldness in the legs, but not in the whole body, was important in the case of kamishoyosan.