Purification and Antihypertensive Activity of a Novel Angiotensin-I Converting Enzyme Inhibitory Peptide from Fish Sauce, <i>Ishiru</i> / 日本補完代替医療学会誌
Japanese Journal of Complementary and Alternative Medicine
;
: 45-49, 2013.
Artículo
en Japonés
| WPRIM
| ID: wpr-376368
ABSTRACT
We purified a novel angiotensin-I converting enzyme (ACE) inhibitor from fish sauce <i>Ishiru</i> prepared from squid, and identified it as the tripeptide Leu-Ala-Arg (LAR). IC<sub>50</sub> of this ACE inhibitor was 2.5 μM, demonstrating high potency among peptides previously purified from fish sauces. Moreover, LAR acted as an antihypertensive peptide, reducing systolic blood pressure in spontaneously hypertensive rats.<br>
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Índice:
WPRIM (Pacífico Occidental)
Idioma:
Japonés
Revista:
Japanese Journal of Complementary and Alternative Medicine
Año:
2013
Tipo del documento:
Artículo
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