Study on Anti-Proliferative Activities of Cultured <i>Cordyceps Militaris </i>on Cancer Cells / 日本補完代替医療学会誌
Japanese Journal of Complementary and Alternative Medicine
;
: 51-57, 2013.
Artículo
en Japonés
| WPRIM
| ID: wpr-376369
ABSTRACT
<i>Cordyceps militaris</i> has been known to produce an anticancer agent, cordycepin. Investigation on optimum culture condition for <i>C. militaris</i> had been performed. In the research program for discovering a novel function in the culture of <i>C. militaris</i>, the culture media was applied to a proliferation assays using various cell lines. The media showed significant anti-proliferative activities against al cell lines, especially to human leukemia cell line HL-60. The activity-guided purification of active ingredient was performed to obtain uracil. To the best of our knowledge, uracil has not been reported to possess anti-proliferative activity. However, the uracil obtained from the culture media was subjected to ICP-MS analysis to reveal that sodium, potassium and magnesium were found to co-exist with uracil, which might show anti-proliferative activity. Further study on the mechanism of the expression of the activity is now underway.<br>
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Índice:
WPRIM (Pacífico Occidental)
Idioma:
Japonés
Revista:
Japanese Journal of Complementary and Alternative Medicine
Año:
2013
Tipo del documento:
Artículo
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