28-day Repeated Dose Oral Toxicity Test of Coix lacryma-jobi L. var. ma-yuen Stapf in Rats / 日本補完代替医療学会誌

ABSTRACT

<i>Coix lacryma-jobi </i>L. var<i>.ma-yuen</i> Stapf (coix seed) is a grass crop that has long been used in traditional medicine as a nourishing food. However, high-intake safety of the extract of the husks, pellicles and astringent skin of coix seed has rarely been evaluated. We performed a 28-day repeated dose oral toxicity test of hot water extract of all parts of Coix seed in rats. The extract showed no significant toxicity on body weight, blood analyses, urinalysis and histopathological examination in acute toxicity tests.<br>