An immediately accessible database for information regarding ingestion timing and maximum dose setting: Development and applications to address inquiries to clarify doubts concerning prescription / 医薬品情報学

ABSTRACT

<b>Objective: </b>Optimizing the time of ingestion and avoiding overdose are important aspects of medication therapy.  However, seeking explanations for selecting the time of ingestion and maximum dose for a certain drug is time consuming.  The aim of this study is to develop a database (DB) that enables a rapid search of the basis for the time of ingestion and maximum dose setting.<br><b>Methods: </b>The basis for the time of ingestion and maximum dose setting were surveyed for 38 and 184 drugs, respectively.  Package inserts, interview forms, and other documents preserved in our department were surveyed, and this was followed by an inquiry of the staff of pharmaceutical companies.  Standard responses to a prescription with incorrect timing or dosage were determined and included into a DB together with information whose quality was dissected.  The efficiency of DB was evaluated the time taken to obtain information and consistency of inquiries to clarify doubts concerning prescription with the use of DB and without the use DB were compared.<br><b>Results: </b>The information of newer drugs, but not of the older drugs, were easily obtained without the need to inquire the staff of the pharmaceutical companies.  Operation of the DB was convenient and was acceptable for most pharmacists working in our department.  The DB markedly reduced the time taken to obtain information.  Further, with the aid of DB, the consistency in the responses to inquiries to clarify doubts concerning a pharmacist’s recommendation was remarkably increased.<br><b>Conclusion: </b>The DB developed in the present study may contribute to the improvement of not only the efficiency but also the quality of dispensation.