<b>Effectiveness of Acupuncture Therapy on </b><i><b>Hiesho </b></i><b>(Cold Disorder) in Maturate Stage Females : A Multicenter, Randomized, Prospective, Controlled T</b><b>rial</b> / 日本東洋医学雑誌

ABSTRACT

<p><b>Objective </b> To determine the effectiveness of acupuncture therapy on <i>hiesho </i>in maturate stage females.<br> <b>Design </b> Multicenter, randomized, prospective, open blind, waiting list-controlled trial.<br><b>Setting </b> A clinical center attached to three universities and one vocational school.<br><b>Participants </b> Twenty two females between 18-39 years of age and with a level of more than four points on the “<i>hiesho </i>sensation scale” proposed by Kusumi et al for <i>hiesho</i>. <b>Interventions </b> Participants were randomly assigned to receive therapies of either acupuncture or no therapy (waiting list controls). Acupuncture therapy was provided by needle retention to SP 6 and electro-acupuncture therapy to BL 32 at a frequency of 1 Hz for 20 minutes. One session per week of this therapy was provided for a total of four sessions. <b>Method of Measurement </b> The primary outcome of change in <i>hiesho </i>intensity was measured using the visual analogue scale (VAS). Secondary changes were measured by an eight heading score and three component summaries of the standard edition SF-36 v 2.<br><b>Results </b> The statistical analyses used an intent-to-treat analysis that included two participants who dropped out, and the mixture of one participant targeted for exclusion who was censored from the analyses. As a result, 21 participants were classified as either in the acupuncture group (n = 12) or the control group (n = 9). Efficacy with acupuncture therapy was not found for effect size (Cohen <i>d</i>, point-biserial correlation <i>r</i>) for VAS and the scores of SF-36 between the two groups.<br><b>Conclusions </b> Effectiveness of the acupuncture therapy was not found, which suggests that it may be due to the smaller sample size, frequency of intervention, and symptoms associated with autonomic dysfunction.</p>